Pseudomonas aeruginosa LasB protease impairs innate immunity in mice and humans by targeting a lung epithelial cystic fibrosis transmembrane regulator–IL-6–antimicrobial–repair pathway
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چکیده
منابع مشابه
Pseudomonas aeruginosa LasB protease impairs innate immunity in mice and humans by targeting a lung epithelial cystic fibrosis transmembrane regulator–IL-6–antimicrobial–repair pathway
BACKGROUND Pseudomonas aeruginosa lung infections are a huge problem in ventilator-associated pneumonia, cystic fibrosis (CF) and in chronic obstructive pulmonary disease (COPD) exacerbations. This bacterium secretes virulence factors that may subvert host innate immunity. OBJECTIVE We evaluated the effect of P. aeruginosa elastase LasB, an important virulence factor secreted by the type II s...
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ژورنال
عنوان ژورنال: Thorax
سال: 2017
ISSN: 0040-6376,1468-3296
DOI: 10.1136/thoraxjnl-2017-210298